许可

发布者:  时间:  浏览:2021-03-23 16:39:42

教师简介

许可,男,讲师,博士研究生邮箱:xuke528@tsinghua.edu.cn

教育经历

2014/09-2018/06 北京理工大学 生物化工 博士

2012/09-2014/09 北京理工大学 生物学 硕士

2002/09-2006/07 燕山大学 生物工程 工学学士

工作经历

2020/12-至今 唐山师范学院 生命科学系

2018/11-2020/11 清华大学化工系 博士后/助理研究员

2014/11-2018/06 中粮营养健康研究院 项目合作

2006/05-2011/03 北京科兴生物制品有限公司

教学情况

微生物学、合成生物学、生物化学实验

目前承担科研项目

1. 酿酒酵母胁迫信号级联传导与阻断调控的分子机制(2020 - 2024)项目负责人 国家自然科学基金面上项目(63万)

2. 合成植物天然产物的微生物细胞工厂构建及应用示范(2019 - 2024)项目核心人员 国家重点研发计划项目(2400万)

获奖情况

1. 2014年国际遗传工程机器竞赛(iGEM)金奖(MIT主办)

2. 2015年国际遗传工程机器竞赛(iGEM)金奖,Nominated for Best New Appliation ProjectMIT主办)

3. 2013-2014年,2015-2016年,2016-2017年优秀研究生

4. 2018届北京理工大学优秀毕业生

论著文章:

1. Xu K, Qin L, Bai W, et al. Multi-level defense system (MDS) relieves multiple stresses for economically boosting ethanol production of industrial Saccharomyces cerevisiae [J]. ACS Energy Letters, 2020, 5: 572-582. If=19.003SCI一区top

2. Xu K, Lv B, Huo Y X, et al. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts [J]. Current Opinion in Biotechnology, 2018, 50: 19-24. If=8.288SCI一区top

3. Xu K, Gao L M, Jalees U H, et al. Improving the thermo-tolerance of yeast base on the antioxidant defense system [J]. Chemical Engineering Science. 2018, 175: 335-342. If=3.871 SCI二区top

4. Xu K, Yu L, et al. Construction of thermo-tolerant yeast based on an artificial protein quality control system (APQC) to improve the production of bio-ethanol [J]. Chemical Engineering Science. 2018, 177: 410-416. If=3. 871SCI二区top

5. Xu K, Lee Y S, Li J, et al. Resistance mechanisms and reprogramming of microorganisms for efficient biorefinery under multiple environmental stresses[J].Synthetic and Systems Biotechnology, 2019, 4(2): 92-98 SCI 收录)

6. Li X1, Xu K1, Fu W, et al. Simultaneous in-situ excess sludge reduction and removal of organic carbon and nitrogen by a pilot-scale continuous aerobicanaerobic coupled (CAAC) process for deeply treatment of soybean wastewater [J]. Biochemical Engineering Journal, 2014, 85: 30-37. If=3.475SCI二区 共同一作)

7. Nadeem A, Xu K, Wang J, et al. Novel catalytic glycosylation of Glycyrrhetinic acid by UDP-Glycosyltransferases from Bacillus subtilis[J]. Biochemical Engineering Journal, 2020, 162: 107723. If=3.475SCI二区)

8. Huangfu J, Kim H S, Xu K, et al. Omics Analysis Reveals the Mechanism of Enhanced Recombinant Protein Production Under Simulated Microgravity[J].Frontiers in Bioengineering and Biotechnology, 2020, 8: 30. If=3.644SCI三区)

9. Jalees U H, Imdaad K, Aamir R, Xu K, et al. Engineered Saccharomyces cerevisiae for the De Novo Synthesis of the Aroma Compound Longifolene[J]. Chemical Engineering Science, 2020, 226: 115799. If=3.871 SCI二区top

10. Qin L, Dong S, Yu J, Xu K, et al. Stress-driven dynamic regulation of multiple tolerance genes improves robustness and productive capacity of Saccharomyces cerevisiae in industrial lignocellulose fermentation[J]. Metabolic Engineering, 2020. 61: 160-170. If=7.263SCI一区top

11. Li C , Gao X , Peng X...Xu K, et al. Intelligent microbial cell factory with genetic pH shooting (GPS) for cell self-responsive base/ acid regulation[J]. Microbial Cell Factories, 2020, 19(1). If=4.187SCI二区)

12. 许可, 吕波, 李春. 无细胞的合成生物技术——多酶催化与生物合成[J].中国科学(化学), 2015, 045(005):429-437.

13. 许可,王靖楠,李春. 智能抗逆微生物细胞工厂与绿色生物制造[J].合成生物学, 202014):407-418.

14. 高小朋, 何猛超, 许可*. 工业微生物发酵过程中pH调控研究进展[J].中国生物工程杂志, 2020, 40(6): 93-99.(通讯作者)

15. 俞杰, 秦磊, 许可,. 细胞工厂氧化还原状态的荧光探针检测与调控[J].生物加工过程, 2020(1):60-69.

获得专利:

授权专利: 一种提高酿酒酵母耐热性的分子调控方法 (ZL103820345A)